Structure of PDB 2hzs Chain B Binding Site BS01

Receptor Information
>2hzs Chain B (length=235) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQQLSLFGSIGDDGYDLLISTLTTISGNPPLLYNSLCTVWKPNPSYDVEN
VNSRNQLVEPNRIKLSKEVPFSYLIDETMMDKPLNFRILESCSPWSLQIS
DIPAAGNNRSVSMQTIAETIILSSAGKNSSVSSLMNGLGYVFEFQYLTIG
VKFFMKHGLILELQKIWQIEEAGNSQITSGGFLLKAYINVSDIDRINYTE
TVLMNLKKELQGYIELSVPDRQSMDSRVAHGNILI
Ligand information
>2hzs Chain I (length=22) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PFNVDDVLKFTFTGEKHHHHHH
Receptor-Ligand Complex Structure
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PDB2hzs Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Q183 F213 Y215 Q237 I246 T247 F251 P291 D292 Q294 S295 M296 S298 L306 I307
Binding residue
(residue number reindexed from 1)		Q114 F144 Y146 Q168 I177 T178 F182 P219 D220 Q222 S223 M224 S226 L234 I235
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006369 termination of RNA polymerase II transcription
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0034605 cellular response to heat
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hzs, PDBe:2hzs, PDBj:2hzs
PDBsum2hzs
PubMed16964259
UniProtP32585|MED18_YEAST Mediator of RNA polymerase II transcription subunit 18 (Gene Name=SRB5)

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