Structure of PDB 2hzl Chain B Binding Site BS01

Receptor Information
>2hzl Chain B (length=337) Species: 272943 (Cereibacter sphaeroides 2.4.1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APKVTWRLASSFPKSLDTIFGGAEVLSKMLSEATDGNFQIQVFSAGELVP
GLQAADAVTEGTVECCHTVGYYYWGKDPTFALAAAVPFSLSARGINAWHY
HGGGIDLYNEFLSQHNIVAFPGGNTGVQMGGWFRREINTVADMQGLKMRV
GGFAGKVMERLGVVPQQIAGGDIYPALEKGTIDATEWVGPYDDEKLGFFK
VAPYYYYPGWWEGGPTVHFMFNKSAYEGLTPTYQSLLRTACHAADANMLQ
LYDWKNPTAIKSLVAQGTQLRPFSPEILQACFEAANEVYAEMEASNPAFK
KIWDSIKAFRSEHYTWAQIAEYNYDTFMMVQQNAGKL
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain2hzl Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hzl Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for alpha-keto acid binding.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		Q156 E214 W215 E240
Binding residue
(residue number reindexed from 1)		Q128 E186 W187 E212
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0043177 organic acid binding
Biological Process
GO:0015849 organic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0031317 tripartite ATP-independent periplasmic transporter complex

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Cellular Component
External links
PDB RCSB:2hzl, PDBe:2hzl, PDBj:2hzl
PDBsum2hzl
PubMed17362499
UniProtQ3J1R2|TAKP_CERS4 Alpha-keto acid-binding periplasmic protein TakP (Gene Name=takP)

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