Structure of PDB 2hu8 Chain B Binding Site BS01

Receptor Information
>2hu8 Chain B (length=573) Species: 56636 (Aeropyrum pernix) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSRIVRDVERLIAVEKYSLQGVVDGDKLLVVGFSEGSVNAYLYDGGETVK
LNREPINSVLDPHYGVGRVILVRDVSKGAEQHALFKVNTSRPGEEQRLEA
VKPMRILSGVDTGEAVVFTGATEDRVALYALDGGGLRELARLPGFGFVSD
IRGDLIAGLGFFGGGRVSLFTSNLSSGGLRVFDSGEGSFSSASISPGMKV
TAGLETAREARLVTVDPRDGSVEDLELPSKDFSSYRPTAITWLGYLPDGR
LAVVARREGRSAVFIDGERVEAPQGNHGRVVLWRGKLVTSHTSLSTPPRI
VSLPSGEPLLEGGLPEDLRRSIAGSRLVWVESFDGSRVPTYVLESGRAPT
PGPTVVLVHGGPFAEDSDSWDTFAASLAAAGFHVVMPNYRGSTGYGEEWR
LKIIGDPCGGELEDVSAAARWARESGLASELYIMGYAYGGYMTLCALTMK
PGLFKAGVAGASVVDWEEMYELSDAAFRNFIEQLTGGSREIMRSRSPINH
VDRIKEPLALIHPQNDSRTPLKPLLRLMGELLARGKTFEAHIIPDAGHAI
NTMEDAVKILLPAVFFLATQRER
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain2hu8 Chain B Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hu8 The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
Resolution2.4 Å
Binding residue
(original residue number in PDB)		F485 R526
Binding residue
(residue number reindexed from 1)		F477 R518
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S42 E43
Catalytic site (residue number reindexed from 1) S34 E35
Enzyme Commision number 3.4.19.1: acylaminoacyl-peptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hu8, PDBe:2hu8, PDBj:2hu8
PDBsum2hu8
PubMed17350041
UniProtQ9YBQ2|APEH_AERPE Acylamino-acid-releasing enzyme (Gene Name=APE_1547.1)

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