Structure of PDB 2hpe Chain B Binding Site BS01

Receptor Information
>2hpe Chain B (length=99) Species: 11709 (Human immunodeficiency virus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGI
GGFINTLEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
Ligand information
Receptor-Ligand Complex Structure
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PDB2hpe The Crystallographic Structure of the Protease from Human Immunodeficiency Virus Type 2 with Two Synthetic Peptidic Transition State Analog Inhibitors
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D25 G27 A28 D29 D30 V47 G48
Binding residue
(residue number reindexed from 1)		D25 G27 A28 D29 D30 V47 G48
Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.47: HIV-2 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2hpe, PDBe:2hpe, PDBj:2hpe
PDBsum2hpe
PubMed
UniProtP04584|POL_HV2RO Gag-Pol polyprotein (Gene Name=gag-pol)

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