Structure of PDB 2h6f Chain B Binding Site BS01

Receptor Information

>2h6f Chain B (length=410) Species: 9606 (Homo sapiens)

SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKF
NHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELL
DEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIG
TEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLT
NIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKR
ERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRA
LHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTC
YCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTY
FLQKPVPGFE

Ligand information

>2h6f Chain P (length=4)

CVLS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2h6f Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): W602 A651 R702 Y861 H862
• Binding residue (residue number reindexed from 1): W88 A137 R188 Y347 H348

Enzymatic activity

• Catalytic site (original residue number in PDB): H748 R791 K794 D797 C799 Y800 D852 D859 H862
• Catalytic site (residue number reindexed from 1): H234 R277 K280 D283 C285 Y286 D338 D345 H348
• Enzyme Commision number: 2.5.1.58: protein farnesyltransferase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004659 prenyltransferase activity
• GO:0004660 protein farnesyltransferase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0008318 protein prenyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006629 lipid metabolic process
• GO:0018343 protein farnesylation

Cellular Component

• GO:0005829 cytosol
• GO:0005875 microtubule associated complex
• GO:0005965 protein farnesyltransferase complex

External links

• PDB: RCSB:2h6f, PDBe:2h6f, PDBj:2h6f
• PDBsum: 2h6f
• PubMed: 16893176
• UniProt: P49356|FNTB_HUMAN Protein farnesyltransferase subunit beta (Gene Name=FNTB)