Structure of PDB 2h5j Chain B Binding Site BS01

Receptor Information
>2h5j Chain B (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFM
HILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYHH
Ligand information
Receptor-Ligand Complex Structure
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PDB2h5j Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Y204 S205 W206 R207 N208 S209 S249 F256
Binding residue
(residue number reindexed from 1)		Y21 S22 W23 R24 N25 S26 S66 F73
Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h5j, PDBe:2h5j, PDBj:2h5j
PDBsum2h5j
PubMed16781734
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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