Structure of PDB 2h4w Chain B Binding Site BS01

Receptor Information
>2h4w Chain B (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV
EEIFRKVRFSFEQPDGRAQMPTTDRVTLTRCFYLFPGH
Ligand information
Receptor-Ligand Complex Structure
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PDB2h4w An allosteric circuit in caspase-1.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S339 W340 R341 H342 R383
Binding residue
(residue number reindexed from 1)		S23 W24 R25 H26 R67
Enzymatic activity
Catalytic site (original residue number in PDB) D390
Catalytic site (residue number reindexed from 1) D74
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h4w, PDBe:2h4w, PDBj:2h4w
PDBsum2h4w
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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