Structure of PDB 2h48 Chain B Binding Site BS01

Receptor Information
>2h48 Chain B (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYAASADV
EEIFRKVRFSFEQPDGRAQMPTTERVTLTRAFYLFPGH
Ligand information
Receptor-Ligand Complex Structure
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PDB2h48 A common allosteric site and mechanism in caspases
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S339 W340 R341 H342 R383
Binding residue
(residue number reindexed from 1)		S23 W24 R25 H26 R67
Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E74
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2h48, PDBe:2h48, PDBj:2h48
PDBsum2h48
PubMed16682620
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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