Structure of PDB 2gk6 Chain B Binding Site BS01

Receptor Information
>2gk6 Chain B (length=602) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRI
AYFTLPLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSV
GAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHE
VEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKT
VTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSR
EAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDLSSADEKRYRALKRTAE
RELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLG
AKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYR
MHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQG
QEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYL
VQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRIGFLNDPRRL
NVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRES
LM
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain2gk6 Chain B Residue 1990 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2gk6 Structural and functional insights into the human Upf1 helicase core
Resolution2.4 Å
Binding residue
(original residue number in PDB)		P494 K498 Q665 R703 R865
Binding residue
(residue number reindexed from 1)		P195 K199 Q362 R400 R556
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2gk6, PDBe:2gk6, PDBj:2gk6
PDBsum2gk6
PubMed17159905
UniProtQ92900|RENT1_HUMAN Regulator of nonsense transcripts 1 (Gene Name=UPF1)

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