Structure of PDB 2gfa Chain B Binding Site BS01
Receptor Information
>2gfa Chain B (length=110) Species:
9606
(Homo sapiens) [
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LQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPED
IVSGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRD
DVYTLDEELP
Ligand information
>2gfa Chain D (length=7) [
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ARTKQTA
Receptor-Ligand Complex Structure
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PDB
2gfa
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
F932 D934 S936 F937 S938 N940 Y942 D945 W967 T968 Y973
Binding residue
(residue number reindexed from 1)
F37 D39 S41 F42 S43 N45 Y47 D50 W66 T67 Y72
Enzymatic activity
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2gfa
,
PDBe:2gfa
,
PDBj:2gfa
PDBsum
2gfa
PubMed
16601153
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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