Structure of PDB 2fu5 Chain B Binding Site BS01

Receptor Information
>2fu5 Chain B (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGHMVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLFLPSMRKDGDLLQ
EHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPIGWHCLDDKNSFYVA
LERVSHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2fu5 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2fu5 Nucleotide exchange via local protein unfolding-structure of Rab8 in complex with MSS4
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C23 C26 C94 C97
Binding residue
(residue number reindexed from 1)		C17 C20 C78 C81
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007264 small GTPase-mediated signal transduction
GO:0015031 protein transport
GO:0061025 membrane fusion
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fu5, PDBe:2fu5, PDBj:2fu5
PDBsum2fu5
PubMed16541104
UniProtP47224|MSS4_HUMAN Guanine nucleotide exchange factor MSS4 (Gene Name=RABIF)

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