Structure of PDB 2fr6 Chain B Binding Site BS01

Receptor Information
>2fr6 Chain B (length=135) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEPEHVQRLLLSSREAKKSAYCPYSRFPVGAALLTGDGRIFSGCNIENAC
YPLGVCAERTAIQKAISEGYKDFRAIAISSDLQEEFISPCGACRQVMREF
GTDWAVYMTKPDGTFVVRTVQELLPASFGPEDLQK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2fr6 Chain B Residue 147 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2fr6 The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse
Resolution2.07 Å
Binding residue
(original residue number in PDB)		C65 C99 C102
Binding residue
(residue number reindexed from 1)		C56 C90 C93
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.5: cytidine deaminase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0019239 deaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006248 CMP catabolic process
GO:0006249 dCMP catabolic process
GO:0009972 cytidine deamination
GO:0030308 negative regulation of cell growth
GO:0044206 UMP salvage
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046898 response to cycloheximide
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071217 cellular response to external biotic stimulus
GO:0072527 pyrimidine-containing compound metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fr6, PDBe:2fr6, PDBj:2fr6
PDBsum2fr6
PubMed16784234
UniProtP56389|CDD_MOUSE Cytidine deaminase (Gene Name=Cda)

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