Structure of PDB 2ffv Chain B Binding Site BS01

Receptor Information
>2ffv Chain B (length=481) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKVRWPDFNQEAYVGGFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPA
TSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALL
GKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPL
LERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTP
EQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLE
ISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEV
WMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPEL
RVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNGNQEWALTKEKS
VKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLC
LDSRTAKSGGLSVEVCGPALSQQWKFTLNLQ
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2ffv Chain B Residue 9600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2ffv Dynamic Association between the Catalytic and Lectin Domains of Human UDP-GalNAc:Polypeptide {alpha}-N-Acetylgalactosaminyltransferase-2
Resolution2.75 Å
Binding residue
(original residue number in PDB)		D224 H226 H359
Binding residue
(residue number reindexed from 1)		D137 H139 H272
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
External links
PDB RCSB:2ffv, PDBe:2ffv, PDBj:2ffv
PDBsum2ffv
PubMed16434399
UniProtQ10471|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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