Structure of PDB 2fbw Chain B Binding Site BS01
Receptor Information
>2fbw Chain B (length=240) Species:
9031
(Gallus gallus) [
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TSRIKKFSIYRWDPDKPGDKPRMQTYEVDLNKCGPMVLDALIKIKNELDS
TLTFRRSCREGICGSCAMNIAGGNTLACTKKIDPDLSKTTKIYPLPHMYV
VKDLVPDLSNFYAQYKSIEPYLKKKDESKQGKEQYLQSIEDRQKLDGLYE
CILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDYTEERLAQLQ
DPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKE
Ligand information
Ligand ID
FES
InChI
InChI=1S/2Fe.2S
InChIKey
NIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0
S1[Fe]S[Fe]1
Formula
Fe2 S2
Name
FE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain
2fbw Chain B Residue 1001 [
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Receptor-Ligand Complex Structure
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PDB
2fbw
3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
Resolution
2.06 Å
Binding residue
(original residue number in PDB)
C65 R66 G68 C70 G71 S72 C73 C85
Binding residue
(residue number reindexed from 1)
C58 R59 G61 C63 G64 S65 C66 C78
Annotation score
1
Enzymatic activity
Enzyme Commision number
1.3.5.1
: succinate dehydrogenase.
Gene Ontology
Molecular Function
GO:0009055
electron transfer activity
GO:0016491
oxidoreductase activity
GO:0051536
iron-sulfur cluster binding
GO:0051537
2 iron, 2 sulfur cluster binding
Biological Process
GO:0006099
tricarboxylic acid cycle
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Molecular Function
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Biological Process
External links
PDB
RCSB:2fbw
,
PDBe:2fbw
,
PDBj:2fbw
PDBsum
2fbw
PubMed
16371358
UniProt
Q9YHT2
|SDHB_CHICK Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Gene Name=SDHB)
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