Structure of PDB 2fai Chain B Binding Site BS01
Receptor Information
>2fai Chain B (length=245) Species:
9606
(Homo sapiens) [
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NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQR
LAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
Ligand information
>2fai Chain D (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQD
Receptor-Ligand Complex Structure
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PDB
2fai
Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 V376 E380 D538 L539 M543
Binding residue
(residue number reindexed from 1)
I55 K59 L69 V73 E77 D235 L236 M240
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:2fai
,
PDBe:2fai
,
PDBj:2fai
PDBsum
2fai
PubMed
16648639
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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