Structure of PDB 2f9y Chain B Binding Site BS01

Receptor Information
>2f9y Chain B (length=257) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVE
LGSELEPKDVLKFRDSKKYKQKETGEKDALVVMKGTLYGMPVVAAAFEFA
FMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMA
KTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFA
GPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLM
NLPAPNP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2f9y Chain B Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2f9y The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme(,).
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C30 C49
Binding residue
(residue number reindexed from 1)		C8 C27
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) G204 G205
Catalytic site (residue number reindexed from 1) G176 G177
Enzyme Commision number 2.1.3.15: acetyl-CoA carboxytransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003989 acetyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006417 regulation of translation
GO:0006633 fatty acid biosynthetic process
GO:0017148 negative regulation of translation
GO:0042759 long-chain fatty acid biosynthetic process
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009317 acetyl-CoA carboxylase complex
GO:0009329 acetate CoA-transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2f9y, PDBe:2f9y, PDBj:2f9y
PDBsum2f9y
PubMed16460018
UniProtP0A9Q5|ACCD_ECOLI Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (Gene Name=accD)

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