Structure of PDB 2f5e Chain B Binding Site BS01

Receptor Information

>2f5e Chain B (length=131) Species: 1423 (Bacillus subtilis)

TTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQKLDKDEY
LIYGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIEHHL
SWNSIDRIGDLVQYFEEDDARKKDLKSIQKK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2f5e Chain B Residue 2150

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2f5e Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): E11 H77 E99 E102
• Binding residue (residue number reindexed from 1): E10 H72 E94 E97
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0046914 transition metal ion binding
• GO:0046983 protein dimerization activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0030026 intracellular manganese ion homeostasis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2f5e, PDBe:2f5e, PDBj:2f5e
• PDBsum: 2f5e
• PubMed: 16533030
• UniProt: P54512|MNTR_BACSU HTH-type transcriptional regulator MntR (Gene Name=mntR)