Structure of PDB 2f55 Chain B Binding Site BS01

Receptor Information
>2f55 Chain B (length=432) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFG
AYMSKAHGIDPNIRTGVRTITTGGSITYSTYGKFLADGGCSGGAYDIIIC
DECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEI
GLSNNGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAV
AYYRGLDVSVIPPIGDVVVVATDALFTGDFDSVIDCNTCVTQTVDFSLDP
TFTIETTTVPQDAVSRSQRRGRTGRGRSGIYRFVTPGERPSGMFDSSVLC
ECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHI
DAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTL
HGPTPLLYRLGAVQNEVILTHPITKYIMACMS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2f55 Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus
Resolution3.3 Å
Binding residue
(original residue number in PDB)		V232 G255 G271 K272 A275 R393 A413 L414 W501 Y502 S548 K551 Q552
Binding residue
(residue number reindexed from 1)		V43 G66 G82 K83 A86 R204 A224 L225 W309 Y310 S356 K359 Q360
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2f55, PDBe:2f55, PDBj:2f55
PDBsum2f55
PubMed16306038
UniProtO92972|POLG_HCVJ4 Genome polyprotein

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