Structure of PDB 2e4v Chain B Binding Site BS01

Receptor Information
>2e4v Chain B (length=520) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAID
EINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLIPLLIAGVIG
GSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQ
AKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKV
GRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTW
VASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHR
NPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAV
YAMAHALHKMQRTLCPQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPN
KGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSI
HWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCM
DCGPGQWPTADLSGCYNLPE
Ligand information
Ligand ID2CG
InChIInChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
InChIKeyMATPZHBYOVDBLI-JJYYJPOSSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1(C(C1C(=O)O)C(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C1([C@H]([C@@H]1C(=O)O)C(=O)O)[C@@H](C(=O)O)N
CACTVS 3.341N[CH]([CH]1[CH]([CH]1C(O)=O)C(O)=O)C(O)=O
ACDLabs 10.04O=C(O)C1C(C(=O)O)C1C(N)C(=O)O
CACTVS 3.341N[C@@H]([C@@H]1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
FormulaC7 H9 N O6
Name(1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid;
(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine;
DCG IV
ChEMBLCHEMBL284193
DrugBank
ZINCZINC000003995770
PDB chain2e4v Chain B Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2e4v Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R64 R68 S149 Y150 S151 A172 S173 T174 Y222 R277 D301 K389
Binding residue
(residue number reindexed from 1)		R37 R41 S102 Y103 S104 A125 S126 T127 Y175 R230 D254 K342
Annotation score1
Binding affinityBindingDB: EC50=300nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e4v, PDBe:2e4v, PDBj:2e4v
PDBsum2e4v
PubMed17360426
UniProtP31422|GRM3_RAT Metabotropic glutamate receptor 3 (Gene Name=Grm3)

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