Structure of PDB 2dtu Chain B Binding Site BS01

Receptor Information
>2dtu Chain B (length=896) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVGEIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDG
PISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQIQS
VFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYV
MSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCS
PNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPN
LSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQI
NRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNE
VCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARE
RMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKR
YALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGE
ESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRG
ILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDL
IKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMFDF
Ligand information
Receptor-Ligand Complex Structure
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PDB2dtu Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family.
Resolution2.37 Å
Binding residue
(original residue number in PDB)		F359 S360 P361 I362 G393 V396 W574 K705 R707 K800 K874
Binding residue
(residue number reindexed from 1)		F352 S353 P354 I355 G386 V389 W567 K698 R700 K793 K867
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2dtu, PDBe:2dtu, PDBj:2dtu
PDBsum2dtu
PubMed17098747
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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