Structure of PDB 2db3 Chain B Binding Site BS01

Receptor Information
>2db3 Chain B (length=420) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSAD
LRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLL
PILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGI
VYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEA
DRMLDMGFSEDMRRIMTHVTMRPEHQTLMFSATFPEEIQRMAGEFLKNYV
FVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQADGTIVFVETKRG
ADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASR
GLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAI
AADLVKILEGSGQTVPDFLR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2db3 Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		P326 T327 R328 G354 G355 T375 G377 R378 D381 R403 F409 E497 T498 K499 H520 G521 R528 T546 V548
Binding residue
(residue number reindexed from 1)		P125 T126 R127 G153 G154 T174 G176 R177 D180 R202 F208 E296 T297 K298 H319 G320 R327 T345 V347
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2db3, PDBe:2db3, PDBj:2db3
PDBsum2db3
PubMed16630817
UniProtP09052|VASA1_DROME ATP-dependent RNA helicase vasa (Gene Name=vas)

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