Structure of PDB 2cyb Chain B Binding Site BS01

Receptor Information
>2cyb Chain B (length=317) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDITEKLRLITRNAEEVVTEEELRQLIETKEKPRAYVGYEPSGEIHLGHM
MTVQKLMDLQEAGFEIIVLLADIHAYLNEKGTFEEIAEVADYNKKVFIAL
GLDESRAKFVLGSEYQLSRDYVLDVLKMARITTLNRARRSMDEVSRRKED
PMVSQMIYPLMQALDIAHLGVDLAVGGIDQRKIHMLARENLPRLGYSSPV
CLHTPILVGLDGQKMSSSKGNYISVRDPPEEVERKIRKAYCPAGVVEENP
ILDIAKYHILPRFGKIVVERDAGDVEYASFEELAEDFKSGQLHPLDLKIA
VAKYLNMLLEDARKRLG
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain2cyb Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2cyb Crystal Structures of Tyrosyl-tRNA Synthetases from Archaea
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y36 G38 L69 A71 H74 Y158 Q162 D165 Q180
Binding residue
(residue number reindexed from 1)		Y36 G38 L69 A71 H74 Y158 Q162 D165 Q180
Annotation score5
Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2cyb, PDBe:2cyb, PDBj:2cyb
PDBsum2cyb
PubMed16325203
UniProtO29482|SYY_ARCFU Tyrosine--tRNA ligase (Gene Name=tyrS)

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