Structure of PDB 2c6w Chain B Binding Site BS01

Receptor Information
>2c6w Chain B (length=384) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNT
DEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQAVETNR
DWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYF
GNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAIS
SNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFS
NVGTRAMKETTAYMMTDMMKTVLTYGTGRNAYLAWLPQAGKTGTSNYTDE
EIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAK
VYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKN
Ligand information
>2c6w Chain A (length=16) Species: 171101 (Streptococcus pneumoniae R6) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TSSKIYDNKNQLIADL
Receptor-Ligand Complex Structure
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PDB2c6w Crystal Structure of Penicillin-Binding Protein 1A (Pbp1A) Reveals a Mutational Hotspot Implicated in Beta-Lactam Resistance in Streptococcus Pneumoniae.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		N267 Y268 L291 G295 M296 D297 V298 Y299 T300 V302 Q304
Binding residue
(residue number reindexed from 1)		N1 Y2 L25 G29 M30 D31 V32 Y33 T34 V36 Q38
Enzymatic activity
Enzyme Commision number 2.4.99.28: peptidoglycan glycosyltransferase.
3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:2c6w, PDBe:2c6w, PDBj:2c6w
PDBsum2c6w
PubMed16316661
UniProtQ8DR59|PBPA_STRR6 Penicillin-binding protein 1A (Gene Name=pbpA)

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