Structure of PDB 2c63 Chain B Binding Site BS01

Receptor Information
>2c63 Chain B (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNV
VGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLS
LLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEA
AYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFD
DAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2c63 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		K50 R57 R132 Y133 L177 N178 N229
Binding residue
(residue number reindexed from 1)		K48 R55 R130 Y131 L175 N176 N227
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0035259 nuclear glucocorticoid receptor binding
GO:0042802 identical protein binding
GO:0044325 transmembrane transporter binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006713 glucocorticoid catabolic process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0021762 substantia nigra development
GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway
GO:0045664 regulation of neuron differentiation
GO:0045893 positive regulation of DNA-templated transcription
GO:0048167 regulation of synaptic plasticity
GO:0050774 negative regulation of dendrite morphogenesis
GO:0086010 membrane depolarization during action potential
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014704 intercalated disc
GO:0070062 extracellular exosome
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0150048 cerebellar granule cell to Purkinje cell synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c63, PDBe:2c63, PDBj:2c63
PDBsum2c63
PubMed17085597
UniProtQ04917|1433F_HUMAN 14-3-3 protein eta (Gene Name=YWHAH)

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