Structure of PDB 2c5v Chain B Binding Site BS01

Receptor Information
>2c5v Chain B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL
Ligand information
Receptor-Ligand Complex Structure
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PDB2c5v Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		M210 W217 E220 R250 Q254 I281 T282
Binding residue
(residue number reindexed from 1)		M36 W43 E46 R76 Q80 I107 T108
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:2c5v, PDBe:2c5v, PDBj:2c5v
PDBsum2c5v
PubMed16492568
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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