Structure of PDB 2c0r Chain B Binding Site BS01

Receptor Information
>2c0r Chain B (length=361) Species: 1397 (Niallia circulans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SERAYNFNAGPAALPLEVLERAQAEFVDYQHTGMSIMEMSHRGAVYEAVH
NEAQARLLALLGNPTGYKVLFIQGGASTQFAMIPMNFLKEGQTANYVMTG
SWASKALKEAKLIGDTHVAASSEASNYMTLPKLQEIQLQDNAAYLHLTSN
ETIEGAQFKAFPDTGSVPLIGDMSSDILSRPFDLNQFGLVYAGAQKNLGP
SGVTVVIVREDLVAESPKHLPTMLRYDTYVKNNSLYNTPPSFGIYMVNEV
LKWIEERGGLEGVQQANRKKASLIYDAIDQSGGFYRGCVDVDSRSDMNIT
FRLASEELEKEFVKASEQEGFVGLKGHRSVGGLRASIYNAVPYESCEALV
QFMEHFKRSRG
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2c0r Chain A Residue 363 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2c0r Effect of Ph on the Structure and Stability of Bacillus Circulans Ssp. Alkalophilus Phosphoserine Aminotransferase: Thermodynamic and Crystallographic Studies.
Resolution1.2 Å
Binding residue
(original residue number in PDB)		N238 T239
Binding residue
(residue number reindexed from 1)		N237 T238
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W103 D173 K197
Catalytic site (residue number reindexed from 1) W102 D172 K196
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c0r, PDBe:2c0r, PDBj:2c0r
PDBsum2c0r
PubMed16532449
UniProtQ59196|SERC_NIACI Phosphoserine aminotransferase (Gene Name=serC)

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