Structure of PDB 2bi3 Chain B Binding Site BS01

Receptor Information
>2bi3 Chain B (length=356) Species: 1445 (Alkalihalobacillus alcalophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KQVFNFNAGPSALPKPALERAQKELLNFNDTQMSVMELSHRSQSYEEVHE
QAQNLLRELLQIPNDYQILFLQGGASLQFTMLPMNLLTKGTIGNYVLTGS
WSEKALKEAKLLGETHIAASTKANSYQSIPDFSEFQLNENDAYLHITSNN
TIYGTQYQNFPEINHAPLIADMSSDILSRPLKVNQFGMIYAGAQKNLGPS
GVTVVIVKKDLLVEQVPTMLQYATHIKSDSLYNTPPTFSIYMLRNVLDWI
KDLGGAEAIAKQNEEKAKIIYDTIDESNGFYVGHAEKGSRSLMNVTFNLR
NEELNQQFLAKAKEQGFVGLNGHRSVGGCRASIYNAVPIDACIALRELMI
QFKENA
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2bi3 Chain A Residue 1361 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2bi3 Strain Relief at the Active Site of Phosphoserine Aminotransferase Induced by Radiation Damage.
Resolution1.69 Å
Binding residue
(original residue number in PDB)		N237 T238
Binding residue
(residue number reindexed from 1)		N233 T234
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W102 D172 K196
Catalytic site (residue number reindexed from 1) W101 D171 K195
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2bi3, PDBe:2bi3, PDBj:2bi3
PDBsum2bi3
PubMed15883191
UniProtQ9RME2|SERC_ALKAL Phosphoserine aminotransferase (Gene Name=serC)

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