Structure of PDB 2au0 Chain B Binding Site BS01

Receptor Information

>2au0 Chain B (length=341) Species: 2287 (Saccharolobus solfataricus)

GIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI

Ligand information

>2au0 Chain H (length=13)

ggttggatggtag

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2au0 Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): A1044 T1045 A1057 G1058 E1106 G1185 G1187 I1189 T1190 K1193 K1221 V1296 S1297 R1298 T1301 K1339
• Binding residue (residue number reindexed from 1): A44 T45 A57 G58 E106 G185 G187 I189 T190 K193 K221 V296 S297 R298 T301 K339

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2au0, PDBe:2au0, PDBj:2au0
• PDBsum: 2au0
• PubMed: 16379496
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)