Structure of PDB 2atx Chain B Binding Site BS01

Receptor Information
>2atx Chain B (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVS
VTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNV
KEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQ
KLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2atx Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2atx An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins
Resolution2.65 Å
Binding residue
(original residue number in PDB)		T31 T49
Binding residue
(residue number reindexed from 1)		T24 T42
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0005525 GTP binding
GO:0019901 protein kinase binding
GO:0032427 GBD domain binding
Biological Process
GO:0006897 endocytosis
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007264 small GTPase-mediated signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0030866 cortical actin cytoskeleton organization
GO:0032869 cellular response to insulin stimulus
GO:0032956 regulation of actin cytoskeleton organization
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046039 GTP metabolic process
GO:0046326 positive regulation of D-glucose import
GO:0051491 positive regulation of filopodium assembly
GO:1903077 negative regulation of protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0045121 membrane raft
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2atx, PDBe:2atx, PDBj:2atx
PDBsum2atx
PubMed16246732
UniProtP17081|RHOQ_HUMAN Rho-related GTP-binding protein RhoQ (Gene Name=RHOQ)

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