Structure of PDB 2amc Chain B Binding Site BS01

Receptor Information
>2amc Chain B (length=785) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRVPFSWLKAYVPELESPEVLEERLAGLGFETDRIERVFPIPRGVVFARV
LEAHPIPGTRLKRLVLDAGRTVEVVSGAENARKGIGVALALPGTELPGLG
QKVGERVIQGVRSFGMALSPRELGVGEYGGGLLEFPEDALPPGTPLSEAW
PEEVVLDLEVTPNRPDALGLLGLARDLHALGYALVEPEAALKAEALPLPF
ALKVEDPEGAPHFTLGYAFGLRVAPSPLWMQRALFAAGMRPINNVVDVTN
YVMLERAQPMHAFDLRFVGEGIAVRRAREGERLKTLDGVERTLHPEDLVI
AGWRGEESFPLGLAGVMGGAESEVREDTEAIALEVACFDPVSIRKTARRH
GLRTEASHRFERGVDPLGQVPAQRRALSLLQALAGARVAEALLEAGSPKP
PEAIPFRPEYANRLLGTSYPEAEQIAILKRLGCRVEGEGPTYRVTPPSHR
LDLRLEEDLVEEVARIQGYETIPLALPAFFPAPDNRGVEAPYRKEQRLRE
VLSGLGFQEVYTYSFMDPEDARRFRLDPPRLLLLNPLAPEKAALRTHLFP
GLVRVLKENLDLDRPERALLFEVGRVFREREETHLAGLLFGEGVGLPWAK
ERLSGYFLLKGYLEALFARLGLAFRVEAQAFPFLHPGVSGRVLVEGEEVG
FLGALHPEIAQELELPPVHLFELRLPLPDKPLAFQDPSRHPAAFRDLAVV
VPAPTPYGEVEALVREAAGPYLESLALFDLYQGPPLPEGHKSLAFHLRFR
HPKRTLRDEEVEEAVSRVAEALRARGFGLRGLDTP
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain2amc Chain B Residue 999 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2amc Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Resolution2.7 Å
Binding residue
(original residue number in PDB)		M260 H261 L286 G315 G318 E334 A356
Binding residue
(residue number reindexed from 1)		M260 H261 L286 G315 G318 E334 A356
Annotation score3
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2amc, PDBe:2amc, PDBj:2amc
PDBsum2amc
PubMed16338408
UniProtQ5SGX1|SYFB_THET8 Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

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