Structure of PDB 2al5 Chain B Binding Site BS01

Receptor Information
>2al5 Chain B (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKN
KWWYDKGECG
Ligand information
Ligand ID4MP
InChIInChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
InChIKeyZXNRTKGTQJPIJK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C2N(C(=O)c1ccc(OC)cc1)CCC2
CACTVS 3.341
OpenEye OEToolkits 1.5.0		COc1ccc(cc1)C(=O)N2CCCC2=O
FormulaC12 H13 N O3
Name1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE;
ANIRACETAM;
1-P-ANISOYL-2-PYRROLIDINONE
ChEMBLCHEMBL36994
DrugBankDB04599
ZINCZINC000000015951
PDB chain2al5 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2al5 Mechanism of positive allosteric modulators acting on AMPA receptors.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		S108 S217
Binding residue
(residue number reindexed from 1)		S106 S215
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2al5, PDBe:2al5, PDBj:2al5
PDBsum2al5
PubMed16192394
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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