Structure of PDB 2afq Chain B Binding Site BS01

Receptor Information
>2afq Chain B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNSVLQVVN
LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSP
FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Ligand information
>2afq Chain A (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GEADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB2afq Crystal structure of wild-type human thrombin in the Na+-free state
Resolution1.93 Å
Binding residue
(original residue number in PDB)		E23 G25 M26 P28 W29 F114 D116 H119 P120 C122 Y134 K135 R137 N159 K202 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 F111 D113 H116 P117 C119 Y134 K135 R137 N150 K198 N203 R204 W205
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E188 G189 D190 S191 G192
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2afq, PDBe:2afq, PDBj:2afq
PDBsum2afq
PubMed16201969
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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