Structure of PDB 2a8g Chain B Binding Site BS01

Receptor Information
>2a8g Chain B (length=121) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KCSLTGKWTNDLGSNMTIGAVNSRGEFTGTYTTAVTATSNEIKESPLHGT
ENTINKRTQPTFGFTVNWKFSESTTVFTGQCFIDRNGKEVLKTMWLLRSS
VNDIGDDWKATRVGINIFTRL
Ligand information
Ligand IDGNG
InChIInChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
InChIKeyYKBGVTZYEHREMT-KVQBGUIXSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc2c(n1C3CC(C(O3)CO)O)NC(=NC2=O)N
ACDLabs 10.04O=C3N=C(N)Nc1c3ncn1C2OC(C(O)C2)CO
CACTVS 3.341NC1=NC(=O)c2ncn([CH]3C[CH](O)[CH](CO)O3)c2N1
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3C[C@@H]([C@H](O3)CO)O)NC(=NC2=O)N
CACTVS 3.341NC1=NC(=O)c2ncn([C@H]3C[C@H](O)[C@@H](CO)O3)c2N1
FormulaC10 H13 N5 O4
Name2'-DEOXY-GUANOSINE
ChEMBLCHEMBL68908
DrugBank
ZINCZINC000000404256
PDB chain2a8g Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2a8g Recognition of oxidatively modified bases within the biotin-binding site of avidin.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		S16 Y33 W70 F72 T77 W97 N118
Binding residue
(residue number reindexed from 1)		S14 Y31 W68 F70 T75 W95 N116
Annotation score4
Binding affinityMOAD: Kd=205uM
PDBbind-CN: -logKd/Ki=3.69,Kd=205uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019731 antibacterial humoral response
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:2a8g, PDBe:2a8g, PDBj:2a8g
PDBsum2a8g
PubMed16413579
UniProtP02701|AVID_CHICK Avidin (Gene Name=AVD)

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