Structure of PDB 1zzc Chain B Binding Site BS01

Receptor Information

>1zzc Chain B (length=179) Species: 43759 (Streptomyces wedmorensis)

TASTGFAELLKDRREQVKMDHAALASLLGETPETVAAWENGEGGELTLTQ
LGRIAHVLGTSIGALTPPAGNDLDDGVIIQMPYYVYNCLVRTKRAPSLVP
LVVDVLTDNPDDAKFNSGHAGNEFLFVLEGEIHMKWGDKENPKEALLPTG
ASMFVEEHVPHAFTAAKGTGSAKLIAVNF

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 1zzc Chain B Residue 199

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zzc Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): H138 E142 H180
• Binding residue (residue number reindexed from 1): H119 E123 H161
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.11.1.23: (S)-2-hydroxypropylphosphonic acid epoxidase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0008198 ferrous iron binding
• GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0017000 antibiotic biosynthetic process
• GO:0051289 protein homotetramerization
• GO:1901766 phosphinothricin biosynthetic process

External links

• PDB: RCSB:1zzc, PDBe:1zzc, PDBj:1zzc
• PDBsum: 1zzc
• PubMed: 16015285
• UniProt: Q56185|HPPE_STRWE (S)-2-hydroxypropylphosphonic acid epoxidase (Gene Name=hppE)