Structure of PDB 1zco Chain B Binding Site BS01

Receptor Information
>1zco Chain B (length=262) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKYSKEYDEKTVVKINDVKFGEGFTIIAGPCSIESREQIMKVAEFLAEVG
IKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHV
ELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSA
EYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPS
HPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQ
LLKELEALGWKG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1zco Chain B Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zco Substrate Ambiguity and Crystal Structure of Pyrococcus furiosus 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase: An Ancestral 3-Deoxyald-2-ulosonate-phosphate Synthase?(,)
Resolution2.25 Å
Binding residue
(original residue number in PDB)
C31 H201 E227 D238
Binding residue
(residue number reindexed from 1)
C31 H201 E227 D238
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0016832 aldehyde-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process

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Molecular Function

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Biological Process
External links
PDB RCSB:1zco, PDBe:1zco, PDBj:1zco
PDBsum1zco
PubMed16142893
UniProtQ8U0A9

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