Structure of PDB 1z7m Chain B Binding Site BS01

Receptor Information
>1z7m Chain B (length=318) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YLLPEESAEMTLNQVKSLRQIEGRLRKLFSLKNYQEVMPPSFEYTQLYTA
LESNGKTFNQEKMFQFIKHEGQSITLRYDFTLPLVRLYSQIKDSTSARYS
YFGKIFRKEKRHKGRSTENYQIGIELFGESADKSELEILSLALQVIEQLG
LNKTVFEIGSAKFFQRLCQLADGSTELLTELLLKKDLSGLNAFIEKNNFS
KELRGLLKEIFITNELSRLENLVTNTKDDVLISSFDQLKEFSEKLSMIKP
IIIDLGMVPKMDYYTDLMFKAYSSAANQPILSGGRYDQLLSNFQEEAFAI
GFCCHMDTILKALERQEL
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1z7m Chain B Residue 329 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1z7m Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K275 Y277
Binding residue
(residue number reindexed from 1)		K270 Y272
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004821 histidine-tRNA ligase activity
GO:0016740 transferase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1z7m, PDBe:1z7m, PDBj:1z7m
PDBsum1z7m
PubMed16051603
UniProtQ02147|HISZ_LACLA ATP phosphoribosyltransferase regulatory subunit (Gene Name=hisZ)

[Back to BioLiP]