Structure of PDB 1z5h Chain B Binding Site BS01

Receptor Information
>1z5h Chain B (length=780) Species: 2303 (Thermoplasma acidophilum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEVEKYDLTLDFDIQKRTFNGTETITADAGDIVLDAVGLQINWMKVNGRD
TAFTYDGQTVRAPGDSQPQKIEISFAGKVSDSLSGIYYAGRENGMITTHF
EATDARRMFPCVDHPAYKAVFAITVVIDKDYDAISNMPPKRIEVSERKVV
EFQDTPRMSTYLLYVGIGKFRYEYEKYRDIDLILASLKDIRSKYPLDMAR
KSVEFYENYFGIPYALPKMHLISVPEFGAGAMENWGAITFREIYMDIAEN
SAVTVKRNSANVIAHEIAHQWFGDLVTMKWWNDLWLNESFATFMSYKTMD
TLFPEWSFWGDFFVSRTSGALRSDSLKNTHPIEVDVRDPDEISQIFDEIS
YGKGASILRMIEDYAGYEEFRKGISKYLNDHKFGNAEGSDLWTAIEDVSG
KPVKRVMEYWIKNPGYPVIKLKRNGRKITMYQTRFLLNGEEEGRWPVPVN
IKKKDGVERILLEDEASIEADGLIKINADSAGFYRVLYDDATFSDVMGHY
RDLSPLDRIGLVDDLFAFLLSGHIDPETYRQRIRNFFDDEDHNVITAIVG
QMEYLRMLTHAFDDDARAFCRSRMQFLTGKQDENLKIALGRVSRLYVMVD
ESYAEEMSKLFKDFDSAEPEMRSSIATAYALVTGDLKGLLEKFRSVDRDE
DRVRIISAFGKLKSNTDLSTVYGMVEKTEIKKQDMISFFSSALETLPGRE
FIFANLDRIIRLVIRYFTGNRTASRTVEMMIPVIGLDHPDAEDIVRNIGS
KNISMGLAKGIEMLAVNRKLVERIRQTAVK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1z5h Chain B Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1z5h Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H265 H269 E288
Binding residue
(residue number reindexed from 1)		H265 H269 E288
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E233 H265 E266 H269 E288 S343 Y351
Catalytic site (residue number reindexed from 1) E233 H265 E266 H269 E288 S343 Y351
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1z5h, PDBe:1z5h, PDBj:1z5h
PDBsum1z5h
PubMed15893768
UniProtO93655|TRF3_THEAC Tricorn protease-interacting factor F3 (Gene Name=trf3)

[Back to BioLiP]