Structure of PDB 1z2w Chain B Binding Site BS01

Receptor Information
>1z2w Chain B (length=182) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLK
TLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLA
LLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSF
VLMDIQASTVVTYVYQLIGDDVKVERIEYKKS
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1z2w Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1z2w Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly
Resolution2.0 Å
Binding residue
(original residue number in PDB)
D8 H10 N39 H117
Binding residue
(residue number reindexed from 1)
D8 H10 N39 H117
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006896 Golgi to vacuole transport
GO:0015031 protein transport
GO:0032456 endocytic recycling
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030904 retromer complex
GO:0030906 retromer, cargo-selective complex
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:1z2w, PDBe:1z2w, PDBj:1z2w
PDBsum1z2w
PubMed15965486
UniProtQ9QZ88|VPS29_MOUSE Vacuolar protein sorting-associated protein 29 (Gene Name=Vps29)

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