Structure of PDB 1yye Chain B Binding Site BS01
Receptor Information
>1yye Chain B (length=224) Species:
9606
(Homo sapiens) [
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LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLN
Ligand information
>1yye Chain D (length=10) [
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HKLVQLLTTT
Receptor-Ligand Complex Structure
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PDB
1yye
ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity
Resolution
2.03 Å
Binding residue
(original residue number in PDB)
I310 K314 V328 L490 E493 M494
Binding residue
(residue number reindexed from 1)
I48 K52 V66 L218 E221 M222
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1yye
,
PDBe:1yye
,
PDBj:1yye
PDBsum
1yye
PubMed
15943471
UniProt
Q92731
|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)
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