Structure of PDB 1ysd Chain B Binding Site BS01

Receptor Information
>1ysd Chain B (length=161) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSSMVTGGMASKWDQKGMDIAYEEALLGYKEGGVPIGGCLINNKDGSVLG
RGHNMRFQKGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGA
IIMYGIPRCVVGENVNFKSKGEKYLQTRGHEVVVVDDERCKKLMKQFIDE
RPQDWFEDIGE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1ysd Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ysd Computational thermostabilization of an enzyme.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H262 C291 C294
Binding residue
(residue number reindexed from 1)		H65 C94 C97
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H262 E264 S289 C291 C294
Catalytic site (residue number reindexed from 1) H65 E67 S92 C94 C97
Enzyme Commision number 3.5.4.1: cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004131 cytosine deaminase activity
GO:0008270 zinc ion binding
GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0019239 deaminase activity
GO:0046872 metal ion binding
Biological Process
GO:0008655 pyrimidine-containing compound salvage
GO:0019858 cytosine metabolic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0044206 UMP salvage
GO:0046087 cytidine metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:1ysd, PDBe:1ysd, PDBj:1ysd
PDBsum1ysd
PubMed15879217
UniProtQ12178|FCY1_YEAST Cytosine deaminase (Gene Name=FCY1)

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