Structure of PDB 1ygr Chain B Binding Site BS01

Receptor Information
>1ygr Chain B (length=574) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KQLMNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVFSKFPIKEARK
PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA
AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR
AFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGV
PEDPHLLLKLRRRVNAFSNFFSGPIVVHSSAGVGRTGTYIGIDAMLEGLE
AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE
LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRN
SNVIPYDYNRVPLKHESKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ
MIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSST
YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKL
PKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARL
GMVSTFEQYQFLYDVIASTYPAQN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1ygr Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y658 V659 D660 R734 H797 S828 S829 A830 V832 G833 R834 L869 Q872
Binding residue
(residue number reindexed from 1)		Y59 V60 D61 R135 H198 S229 S230 A231 V233 G234 R235 L270 Q273
Enzymatic activity
Catalytic site (original residue number in PDB) D796 S828 R834 T835 Q872
Catalytic site (residue number reindexed from 1) D197 S229 R235 T236 Q273
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1ygr, PDBe:1ygr, PDBj:1ygr
PDBsum1ygr
PubMed15684325
UniProtP08575|PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (Gene Name=PTPRC)

[Back to BioLiP]