Structure of PDB 1yaa Chain B Binding Site BS01

Receptor Information
>1yaa Chain B (length=412) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SATLFNNIELLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLP
SVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQSDALQEDRVI
SVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTAT
YPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQ
IVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQ
SFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPA
YGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPGNW
DHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASGRASIAGLNQGNVEYV
AKAIDEVVRFYA
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1yaa Chain B Residue 906 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1yaa Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		S107 G108 T109 W140 N194 D222 A224 Y225 S255 K258 R266
Binding residue
(residue number reindexed from 1)		S106 G107 T108 W134 N187 D215 A217 Y218 S251 K254 R262
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W140 D222 A224 K258
Catalytic site (residue number reindexed from 1) W134 D215 A217 K254
Enzyme Commision number 2.6.1.1: aspartate transaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0043023 ribosomal large subunit binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006520 amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006536 glutamate metabolic process
GO:0009058 biosynthetic process
GO:0032938 negative regulation of translation in response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1yaa, PDBe:1yaa, PDBj:1yaa
PDBsum1yaa
PubMed9655342
UniProtP23542|AATC_YEAST Aspartate aminotransferase, cytoplasmic (Gene Name=AAT2)

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