Structure of PDB 1xpo Chain B Binding Site BS01

Receptor Information

>1xpo Chain B (length=408) Species: 562 (Escherichia coli)

MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIF
GDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGK
IRPPKEGERYFALLKVNEVNFDKPENNKILFENLTPLHANSRLRMGSTED
LTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMV
LLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEH
KKDVIILLDSITRLARAYNTVVPAVLTGGVDANALHRPKRFFGAARNVEE
GGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAID
YNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTN
DDFFEMMK

Ligand information

>1xpo Chain M (length=2)

uc

..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1xpo Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin
• Resolution: 3.15 Å
• Binding residue (original residue number in PDB): L58 F62 F64 A74 D78 Y80 E108 R109 Y110
• Binding residue (residue number reindexed from 1): L58 F62 F64 A74 D78 Y80 E108 R109 Y110

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0004386 helicase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008186 ATP-dependent activity, acting on RNA
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0042802 identical protein binding

Biological Process

• GO:0006353 DNA-templated transcription termination

Cellular Component

• GO:0005829 cytosol
• GO:0016020 membrane

External links

• PDB: RCSB:1xpo, PDBe:1xpo, PDBj:1xpo
• PDBsum: 1xpo
• PubMed: 15642265
• UniProt: P0AG30|RHO_ECOLI Transcription termination factor Rho (Gene Name=rho)