Structure of PDB 1x27 Chain B Binding Site BS01
Receptor Information
>1x27 Chain B (length=164) Species:
9606
(Homo sapiens) [
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MNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIP
FNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGS
FSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNA
SDGLCTRLSRPCQT
Ligand information
>1x27 Chain J (length=6) Species:
10116
(Rattus norvegicus) [
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DYDYVH
Receptor-Ligand Complex Structure
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PDB
1x27
Molecular basis for regulation of Src by the docking protein p130Cas
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
R134 R154 S156 E157 S158 S164 K179 H180 Y181 K182 I193 S194 R196 G215
Binding residue
(residue number reindexed from 1)
R72 R92 S94 E95 S96 S102 K117 H118 Y119 K120 I131 S132 R134 G153
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:1x27
,
PDBe:1x27
,
PDBj:1x27
PDBsum
1x27
PubMed
16245368
UniProt
P06239
|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)
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