Structure of PDB 1wz2 Chain B Binding Site BS01

Receptor Information
>1wz2 Chain B (length=948) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNFKAIEEKWQKRWLEAKIFEPNIRDKPKEKKFYITVAFPYLSGHLHVGH
ARTYTIPDVIARFKRMQGYNVLFPMAWHITGSPIVGIAERIKNRDPKTIW
IYRDVYKVPEEILWTFEDPINIVKYFMKAAKETFIRAGFSVDWSREFYTT
SLFPPFSKFIEWQFWKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGED
VPILDYIIIKFELRENGEVIYLPAATLRPETVYGVTNMWVNPNATYVKAK
VRRKDKEETWIVSKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVSGD
EVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRETEILEKYDIDP
RIVFPAVEEVNKLGIKSQKDKEKLEQATKTIYKAEYHKGIFKVPPYEGKP
VQEVKEAIAKEMLEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDY
GNPEWKEKARKALERMKILPETRRAQFEAIIDWLDKKACARKIGLGTPLP
WDPEWVIESLSDSTIYMAYYTISRHINKLRQEGKLDPEKLTPEFFDYIFL
EEFSEDKEKELEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLT
FFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIEENG
ADVVRLYIMSLAEHDSDFDWRRKEVGKLRKQIERFYELISQFAEYEVKGN
VELKDIDRWMLHRLNKAIKETTNALEEFRTRTAVQWAFYSIMNDLRWYLR
RTEGRDDEAKRYVLRTLADVWVRLMAPFTPHICEELWEKLGGEGFVSLAK
WPEPVEEWWNETIEAEEEFIRSVMEDIKEIIEVAKIENAKRAYIYTAEDW
KWKVAEVVSEKRDFKSSMEELMKDSEIRKHGKEVAKIVQKLIKERTFDVK
RINEEKALREAKEFMEKELGIEIIINPTEDKGGKKKQAMPLKPAIFIE
Ligand information
>1wz2 Chain D (length=88) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcggggguugccgagccuggucaaaggcgggggacucaagauccccuccc
guagggguuccgggguucgaauccccgcccccgcacca
<<<<<<<..<<<.............>>><<<<<<.......>>>>>><<<
....>>>...<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB1wz2 The crystal structure of Leucyl-tRNA synthetase and tRNA(leucine) complex
Resolution3.21 Å
Binding residue
(original residue number in PDB)		P86 H181 G194 H406 F466 L503 D504 K505 K506 A507 R510 L529 K696 R750 R765 D845 E848 I849 K854 K961 P962 A963 I964 F965 I966
Binding residue
(residue number reindexed from 1)		P83 H178 G191 H387 F447 L484 D485 K486 K487 A488 R491 L510 K677 R731 R746 D826 E829 I830 K835 K942 P943 A944 I945 F946 I947
Enzymatic activity
Catalytic site (original residue number in PDB) I567 L613 F623 K650 K653
Catalytic site (residue number reindexed from 1) I548 L594 F604 K631 K634
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1wz2, PDBe:1wz2, PDBj:1wz2
PDBsum1wz2
PubMed
UniProtO58698|SYL_PYRHO Leucine--tRNA ligase (Gene Name=leuS)

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