Structure of PDB 1u8g Chain B Binding Site BS01

Receptor Information
>1u8g Chain B (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Ligand information
Receptor-Ligand Complex Structure
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PDB1u8g Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex.
Resolution2.201 Å
Binding residue
(original residue number in PDB)		R8 L23 D25 G27 A28 D30 I47 G48 G49 I50 V82
Binding residue
(residue number reindexed from 1)		R8 L23 D25 G27 A28 D30 I47 G48 G49 I50 V82
Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1u8g, PDBe:1u8g, PDBj:1u8g
PDBsum1u8g
PubMed15502300
UniProtP03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)

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