Structure of PDB 1u3f Chain B Binding Site BS01

Receptor Information

>1u3f Chain B (length=164) Species: 2104 (Mycoplasmoides pneumoniae)

MDKNALRKQILQKRMALSTIEKSHLDQKINQKLVAFLTPKPCIKTIALYE
PIKNEVTFVDFFFEFLKINQIRAVYPKVISDTEIIFIDQETNTFEPNQID
CFLIPLVGFNKDNYRLGFGKGYYDRYLMQLTRQQPKIGIAYSFQKGDFLA
DPWDVQLDLIINDE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1u3f Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1u3f Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): D124 D154
• Binding residue (residue number reindexed from 1): D124 D154
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): R115 D124 D154
• Catalytic site (residue number reindexed from 1): R115 D124 D154
• Enzyme Commision number: 6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0035999 tetrahydrofolate interconversion

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1u3f, PDBe:1u3f, PDBj:1u3f
• PDBsum: 1u3f
• PubMed: 15281135
• UniProt: P75430|MTHFS_MYCPN 5-formyltetrahydrofolate cyclo-ligase (Gene Name=MPN_348)