Structure of PDB 1u0l Chain B Binding Site BS01

Receptor Information

>1u0l Chain B (length=278) Species: 2336 (Thermotoga maritima)

LRRRGIVVSFHSNMVTVEDEETGERILCKLRGKFRLQNLKIYVGDRVEYT
PDETGSGVIENVLHRKNLLTKPHVANVDQVILVVTVKMPETSTYIIDKFL
VLAEKNELETVMVINKMDLYDEDDLRKVRELEEIYSGLYPIVKTSAKTGM
GIEELKEYLKGKISTMAGLSGVGKSSLLNAINPGLKLRTTTTAQLLKFDF
GGYVVDTPGFANLEINDIEPEELKHYFKEFGDKQCFFSDCNHVDEPECGV
KEAVENGEIAESRYENYVKMFYELLGRR

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1u0l Chain B Residue 598

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1u0l Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): C550 C555 H557 C563
• Binding residue (residue number reindexed from 1): C235 C240 H242 C248
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.1.-

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1u0l, PDBe:1u0l, PDBj:1u0l
• PDBsum: 1u0l
• PubMed: 15331784
• UniProt: Q9X242|RSGA_THEMA Small ribosomal subunit biogenesis GTPase RsgA (Gene Name=rsgA)