Structure of PDB 1u08 Chain B Binding Site BS01

Receptor Information
>1u08 Chain B (length=378) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLIPQSKLPTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQ
GANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAI
TALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQPPHFRVDWQEFAA
LLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGHEIFVISDEVYEHI
NFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPISAEI
RKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFYRQKRDILVNALNE
SRLEILPCEGTYFLLVDYSAVSTLDDVEFCQWLTQEHGVAAIPLSVFCAD
PFPHKLIRLCFAKKESTLLAAAERLRQL
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1u08 Chain B Residue 1400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1u08 Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function
Resolution2.35 Å
Binding residue
(original residue number in PDB)		G99 A100 T101 Y125 N170 N174 D202 V204 Y205 S233 K236 K244
Binding residue
(residue number reindexed from 1)		G91 A92 T93 Y117 N162 N166 D194 V196 Y197 S225 K228 K236
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.88: methionine transaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0010326 methionine-oxo-acid transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0009058 biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u08, PDBe:1u08, PDBj:1u08
PDBsum1u08
PubMed15280032
UniProtP77806|YBDL_ECOLI Methionine aminotransferase (Gene Name=ybdL)

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