Structure of PDB 1twx Chain B Binding Site BS01

Receptor Information
>1twx Chain B (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCARKGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
>1twx Chain A (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB1twx Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form
Resolution2.4 Å
Binding residue
(original residue number in PDB)		E23 I24 M26 P28 W29 D116 H119 P120 C122 L129C Y134 K135 R137 N159 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 I9 M11 P13 W14 D113 H116 P117 C119 L129 Y134 K135 R137 N157 K205 R211 W212
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1twx, PDBe:1twx, PDBj:1twx
PDBsum1twx
PubMed15572256
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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